Kanadia Lab Updates
08-31-2020 Welcome to the new graduate students of the Kanadia Lab: Saren Smith, Madisen Lee, and Beom Jin Park.
08-17-2020 Congratulations to Alisa White for being awarded the UCONN Neuroscience Fellowship!
08-14-2020 Go check out Kyle Drake's Newest publication in Development! https://dev.biologists.org/content/147/21/dev190967
Congrats to Kyle for successfully completing his qualifying exams!
04-2-2020 Introducing Dr. Anouk Olthof! Congratulations Anouk for successfully defending your thesis and receiving your Ph.D. in PNB.
02-15-2020 Congratulations Anouk on accepting a PostDoc position with Dr. Svejstrup at the Crick Institute, London, UK
Rahul N. Kanadia, Ph.D.
|Office:||Torrey Life Sciences Building, room 121|
|Lab:||Pharmacy and Biology Building, room 116|
Department of Physiology & Neurobiology
University of Connecticut
75 North Eagleville Road, U3156
Storrs, CT 06269
Our long-term objective is to understand the role of post-transcriptional regulation of gene expression in embryonic development and disease pathogenesis. Specifically, we focus on understanding the role of the minor spliceosome, which is responsible for the splicing of a rare type of intron called the U12-type or minor intron. In the mammalian genome <0.5% of the introns require the minor spliceosome and are often found embedded as single introns in genes that otherwise consist of introns spliced by the major spliceosome. Thus, regulation of these minor intron-containing genes (MIGs) requires coordinated action of both the major and the minor spliceosome. We aim to study how this coordination between the major and minor spliceosome controls expression of MIGs in stem cells. Specifically, we want to understand how minor intron splicing and MIG-expression inform self-amplification versus differentiative cell division. To study this, we primarily use mouse as the model organism. We employ molecular and biochemical methodologies in the developing mouse embryo combined with bioinformatics to understand splicing and alternative splicing of MIGs.